A field experiment was conducted during the Rabi (winter) season of 2014-15 and 2015-16 at Agricultural Research Station, Dharwad, Karnataka, India to evaluate the efficacy of tank mix herbicides and premix herbicides on weed control and its influence on productivity and profitability in irrigated wheat. Tank mix application of sulfosulfuron + metsulfuron 25 + 4 g/ha recorded significantly higher grain yield (4.31 t/ha) followed by clodinafop + metsulfuron 60 + 4 g/ha (4.15 t/ha) over weedy check. Biological yield was recorded significantly higher with clodinafop + metsulfuron 60 + 4 g/ha (12.21 t/ha) followed by sulfosulfuron + metsulfuron 25 + 4 g/ha (12.18 t/ha) over 2,4-D 2.5 kg/ha (10.68 t/ha) alone. The lower weed density, weed biomass and higher weed control efficiency was recorded with sulfosulfuron + metsulfuron 25 + 4 g/ha followed by clodinafop + metsulfuron 60 + 4 g/ha compared to weedy check. The more gross returns, net returns and benefit : cost ratio was obtained with sulfosulfuron + metsulfuron 25 + 4 g/ha over other weed management practices.