A field experiment was carried out during the Rabi season of 2014 and 2015 on sandy loam soil to test the bio-efficacy of pre-mix broad spectrum herbicides for weed management in wheat. Major dominant weed flora in the experimental plot were Chenopodium murale (54.1%), Chenopodium album (11.9%), Phalaris minor (10.4%) and Melilotus alba (9.6%). Application of pre-mix sulfosulfuron (75%) + metsulfuron-methyl (5%) 32 g/ha as post-emergence, clodinafop  (15%) + metsulfuron-methyl (1.0%) 64 g/ha as post-emergenc (PoE), mesosulfuron (3%) + iodosulfuron-methyl sodium (0.6 %) 14.4 g/ha as PoE and hand weeding  at 20 and 40 DAS remained at par with each other and significantly reduced the density and biomass of both monocot as well as dicot weeds and resulted in significantly more number of effective tillers and yield of grain and straw. However, mesosulfuron (3%) + iodosulfuron-methyl sodium (0.6 %) 14.4 g/ha PoE showed phytotoxic effect on plant.