Bio-efficacy of triafamone (20%) + ethoxysulfuron (10%) (ready-mix, 30% WG) was evaluated as early post-emergence (1-2 leaf stage of weeds, 15 days after transplanting) against complex weed flora in transplanted rice at CCS Haryana Agricultural University Regional Research Station, Karnal during Kharif 2011 and 2012, phyto-toxicity on transplanted rice during Kharif 2012 and 2013 and its residual phyto-toxicity on wheat during Rabi 2012-13 and 2013-14. Triafamone + ethoxysulfuron 60-67.5 g/ha proved superior or at par with other herbicidal treatments in reducing the dry weight of grassy and broad-leaf weeds to the extent of >99% and 85-94%, respectively, and provided almost complete control of sedges (Cyperus difformis and Fimbristylis miliaceae) during both the years. There was no significant effect of different treatments on the plant height and panicle length of the rice during both the years. Application of triafamone + ethoxysulfuron 60 g/ha resulted in number of effective tillers (58.7/mrl in 2011 and 78.2/mrl in 2012) at par with triafamone 45 g/ha, butachlor 1250 and 1500 g/ha, and also weed free check during both the years. The grain yield of rice (6.08 t/ha in 2011 and 7.06 t/ha in 2012) due to triafamone + ethoxysulfuron 60 g/ha was higher than its lower dose (52.5 g/ha) but at par with the higher dose (67.5 g/ha), triafamone 45 g/ha, butachlor 1500 g/ha and weed free check during 2011 and 2012; butachlor 1250 g/ha and pretilachlor 1000 g/ha during 2012; but superior to all other herbicidal treatments during both the years. There were no visual phyto-toxicity symptoms of triafamone + ethoxysulfuron on rice crop and also no residual phyto-toxicity on succeeding wheat crop even up to 120 g/ha.