A field experiment was conducted during Rabi seasons of 2006-07 and 2007-08 at Research Farm of GBPUA&T, Krishi Vigyan Kendra Dhakrani, Dehradun to study the effect of weed control practices on weed dyanamics, nutrient uptake and yield of wheat (Triticum aestivum (L.) emend. Fiori and Paol). Results revealed that application of clodinafop-propargyl + metsulfuron-methyl (60+4 g/ha) being on at par with clodinafop propargyl + 2,4-D (60+500 g/ha) reduced the weed population significantly over weedy check (97.2%) and other weed control treatments. Clodinafop-propargyl+ metsulfuron-methyl (60+4 g/ha) applied as post-emergence (35 DAS) recorded 14.3, 15.5, 23.7, 29.5, 45.9, 47.4 and 69.7 per cent more grain yield over pendimethalin, isoproturon + metsulfosulfuron-methyl, fenoxaprop-p-ethyl + metsulfuron-methyl, fenoxaprop-p-ethyl, isoproturon, clodinafop-propargyl and weedy check, respectively. The weeds removed the 28.7 kg of N, 13.4 kg P2O5 and 21.5 kg of K2O/ha, and reduced the wheat grain yield by 78.8% as compare to weed free conditions. Application of clodinafop-propargyl + metsulfuron-methyl reduced the nutrients removal by weeds and increased its removal by wheat.