A field experiment was conducted during Kharif season of 2007 to study the weed management in pearlmillet inter-cropping systems. The experiment was laid out in factorial randomized block design and replicated three times. Pre-emergence application of pendimethalin at 0.75kg/ha and oxyfluorfen at 0.2 kg/ha decreased the crop growth and yield attributes, viz. plant stand, plant height, dry matter production, root weight and root length compared to two hand weeding due to some phytotoxic effect but superior to one hand weeding and weedy check. Significantly higher seed, stover, biological and pearlmillet equivalent yield were recorded in two hand weeding treatment over all other treatments except weed free. The N and P uptake of pearlmillet and net returns increased significantly under all the weed control treatments as compared to weedy check.