A field trial was conducted during Kharif 2012 at Agricultural Research Farm, Institute of Agricultural sciences, Banaras Hindu University, Varanasi, Uttar Pradesh (India) to study effect of rice establishment and integrated weed management practices on weed growth and grain yield. Pendimethalin 1.0 kg/ha fb azimsulfuron 17.5 g/ha + bispyribac 25 g/ha 15 DAS fb 1 HW significantly reduced weed density and weed biomass in comparison to oxadiagryl 50 g/ha fb metsulfuron-methyl 2 g/ha + chlorimuron-ethyl 2 g/ha 20 DAS fb 1 HW. Rice grain yield in CT paired row was statistically at par with CT normal spacing, CT square planting and RT paired row. It was significantly higher as compared to RT square planting. Amongst weed management practices, pendimethalin 1 kg/ha fb azimsulfuron 17.5 g/ha + bispyribac 25g/ha fb 1HW recorded higher rice grain yield attributing characters viz. number of panicles/m2, number of grains/panicle, test weight and grain yield and it was found significantly better than oxadiagryl 50 g/ha fb metsulfuron methyl 2g/ha+ chlorimuron-ethyl 2g/ha fb 1 HW.