An experiment was conducted at Kole lands in Thrissur district, Kerala to study the efficacy of various post-emergence herbicides in wet-seeded rice. The results showed that cyhalofop-butyl + chlorimuron-ethyl+ metsulfuron-methyl, fenoxaprop-p-ethyl + chlorimuron-ethyl+ metsulfuron-methyl and bispyribac-sodium were best treatments with a lower weed biomass as well as high grain yield and B:C ratio. Maximum weed control efficiency of 97.1% was obtained in hand weeded plots followed by bispyribac-sodium (93.6%). The highest grain yield of 6.13 t/ha was recorded in hand weeded plot which was at par with cyhalofop-butyl + chlorimuron-ethyl + metsulfuron-methyl and fenoxaprop + chlorimuron ethyl+ metsulfuron-methyl (5.8 t/ha). From this study it can be concluded that, cyhalofop-butyl with a follow up spray of chlorimuron-ethyl + metsulfuron-methyl or fenoxaprop-p-ethyl with a follow up spray of chlorimuron-ethyl + metsulfuron methyl or bispyribac sodium alone can be recommended for effective post emergence weed control and higher yield in wet seeded rice. If grasses are the predominant weeds, cyhalofop-butyl or fenoxaprop-p-ethyl alone without follow up spray of chlorimuron-ethyl + metsulfuron-methyl can also be recommended.