Ten on-farm trials (OFTs) were carried out at farmers’ fields in participatory mode during the Rabi season of 2007-08 to 2008-09 in selected adjoining villages to the Krishi Vigyan Kendra, Azamgarh of eastern Uttar Pradesh. The main objectives of activities were to evaluate the performance and profitability of zero tillage and herbicides on weed control and productivity of wheat crop under rice-wheat cropping system. Zero till sown wheat was found much effective in suppression of weed density and population of Phalaris minor in comparison to conventional tillage. A drastic reduction in weed density was obtained with the application of sulfosulfuron + metsulfuron methyl 75 WG at 40 g/ha ready-mix under both method of wheat sowing. The higher average grain yield and monitory returns were also achieved under zero tillage sown wheat combined with sulfosulfuron + metsulfuron methyl as post emergence. However, grain yield obtained under zero tillage was almost comparable to conventional tillage with fenoxaprop-p-ethyl 10 EC at 1000 ml/ha.