A field experiment was conducted to study the efficacy of different pre- and post-emergence herbicides and their combinations to control the weeds in soybean during Kharif season of the year- 2012. Application of imazethapyr 0.100 kg/ha + quizalofop-ethyl 0.075 kg/ha as post-emergence was found to be more efficient to control monocot and dicot weeds in soybean which recorded lowest weed density, dry matter and weed index. It also found superior in respect of various growth and yield attributes. Highest seed yield (2.45 t/ha) and straw yield of soybean and maximum gross return (` 81,500/-) and net return (` 56,269/-) were also recorded in imazethapyr 0.100 kg/ha + quizalofop-ethyl 0.075 kg/ha as postemergencewith highest B:C ratio of 3.23. It was also found responsible for highest uptake of N, P and K by soybean crop and lowest uptake of these plant nutrients by weed plants.