Field experiment was conducted to evaluate the bio-efficacy of ametryn 73.15% + trifloxysulfuron 1.85% W.G for the management of grasses, sedge and broad-leaf weeds in sugarcane. The experiment consisted of nine treatments laid out in randomized block design with three replications. Cyperus rotundus, Ipomoea spp, Brachiaria reptans, Echinochloa colona, Digitaria sanguinalis and Dactyloctenium aegyptium were observed as major weeds. Among herbicide treatments, the lowest density of total weeds was observed with ametryn + trifloxysulfuron at 1500 g/ha though the differences were non-significant when compared with its lower dose i.e. 1250 g/ha at 15 and 45 days after application (DAA). Application of ametryn + trifloxysulfuron 1250 and 1500 g/ha recorded significantly lower weed dry weight over any other herbicidal treatment at 15 and 45 days. Highest weed control efficiency of total weeds at both 15 and 45 DAA were recorded with the application of ametryn + trifloxysulfuron 1500 g/ha which was closely followed by 1250 g/ha. The highest cane yields (9.04 t/ha and 10.51 t/ha) were recorded from weed free plot being at par with hand weeding thrice at 30, 60 and 90 DAP.