Field experiment was conducted during Kharif 2014 to evaluate weed control efficiency of different herbicides for weed management and their effect on cotton crop. Highest seed cotton yield (3.55 t/ha) was recorded in weed free plots followed by pyrithiobac-sodium 62.5 g/ha + quizalofop-ethyl 50 g/ha + one hoeing (3.52 t/ha) owing to improved number of bolls per plant and boll weight. Statistically least yield was recorded under weedy check (1.92 t/ha). Weed control efficiency (WCE) was highest under weed free check (90.3%) followed by pendimethalin 1.0 kg/ha + quizalofop-ethyl 50 g/ha + one hoeing (71.0%), whereas minimum for weedy check (25.5%). Net returns (` 100916/ha) and B:C ratio (2.14) were highest for pyrithiobac-sodium 62.5 g/ha + quizalofop-ethyl 50 g/ha + one hoeing. Therefore, this set of chemicals combination along with cultural practices could be the practical solution for economically efficient and effective weed management in cotton.