A field experiment was conducted at Agricultural Research Farm, Institute of Agricultural sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, during rainy season of 2011 and 2012 to study the effect of nitrogen schedule and weed management in direct-seeded rice under irrigated condition. The experiment comprised of 24 treatments including all the combinations of four nitrogen schedule and six weed management. The results indicated that the minimum weed density, total weed dry weight and depletion of nutrient was recorded under nitrogen schedule of ¼ 2 WAS (week after sowing) + ¼ 4 WAS + ¼ 6 WAS+ ¼ 8 WAS, which was statistically at par with 1/3 2 WAS + 1/3 4 WAS + 1/3 6 WAS and significantly lower than other nitrogen schedules. The maximum yield was recorded under nitrogen schedule at ¼ 2 WAS + ¼ 4 WAS + ¼ 6 WAS + ¼ 8 WAS, which was statistically at par with 1/3 2 WAS + 1/3 4 WAS + 1/3 6 WAS and which was significantly superior over other treatments. Significantly lower weed density, dry weight and nutrient depletion were recorded under application of pendimethalin 1.0 kg/ha fb bispyribac + carfentrazone (25 + 20 g/ha) and pendimethalin 1.0 kg/ha fb bispyribac + ethoxysulfuron (25 +18 g/ha), which were significantly superior over other treatments.