A field experiment was conducted at S.V. Agricultural College Farm, Tirupati during summer, 2015 in a randomized block design with eleven weed management practices consisting of pre-emergence application of pendimethalin 750 g/ha, oxyfluorfen 75 g/ha, oxadiargyl 75 g/ha alone and in combination with post-emergence application of quizalofop 50     g/ha and propaquizafop 60 g/ha at 20 DAS, two hand weedings and unweeded check. The lowest density and dry weight of weeds with higher weed control efficiency, higher stature of yield components and seed yield of broadcasted sesame were registered with two hand weedings at 20 and 40 DAS. The next best weed management practice for broad spectrum weed control and increased seed yield of broadcasted sesame was with pre-emergence application of oxyfluorfen 75 g/ha + quizalofop 50 g/ha applied at 20 DAS. Pre-emergence application of oxadiargyl 75 g/ha alone or in combination with post-emergence herbicides failed to control the weeds as the pre-emergence application of oxadiargyl recorded phytotoxicity rating of 4.0 on sesame seedlings in 0-10 scale in sandy loam soils.