Field experiments were conducted for two years at wetland farm, Tamil Nadu Agricultural University, during Kharif seasons of 2014 and 2015 (June to October) to evaluate the penoxsulam (21.7% SC) for weed control in rice. Based on two years data, it was found that pre-emergence application of penoxsulam 22.5 g/ha resulted in significantly lower total weed density, weed dry weight and higher weed control efficiency at all the intervals. Application of penoxsulam could keep the weed density and dry weight below the economic threshold level and increase grain yield of 5.21 and 5.04 t/ha was obtained in 2014 and 2015, respectively. Unweeded control accounted for lower grain yield and higher weed index of 48.7 and 60.8%, respectively.