Field experiments were conducted in Safsaf area in Libya during growing season of 2009-10 and 2010-11.  The field infested with many weeds of mixed flora was used to investigate the efficacy of clodinafop, isoproturon and their sequential application in ‘Zorda’ cultivar of durum wheat during different crop growth stages that is seedling, tillering and elongation in the presence or absence of diammonium phosphate (DAP) at 2.5 t/ha. Results revealed that all weed control treatments reduced weed density and dry weight recorded at 60 days of sowing.  The least weed density was recorded from sequential application of clodinafop and isoproturon compared to weedy check.  Herbicide application at seedling stage of crop growth in the absence of DAP was more effective in reducing weeds density and their dry weight.  Crop height, effective tillers, biological yield, grain and straw yield, seed and harvest index increased due to sequential application of clodinafop and isoproturon during seedling stage in the presence of DAP compared to weedy check and elongation stage in the absence of DAP.