The field study was undertaken during rainy season of 2012 and 2013 to evaluate the rice cultivars and weed management effects on weeds growth and yield of direct-seeded rice (DSR) cultivars. The associated weed flora include Echinochloa colona, Echinocloa crus-galli, Cynodon dactylon as grasses; Cyperus rotundus, Cyperus iria as sedges; Caesulia auxillaries and Eclipta alba as broad-leaved weeds. Bispyribac-sodium  + azimsulfuron (25 + 35 g/ha) + 0.25% NIS as post-emergence at 15-20 DAS was found to be most effective in minimizing weed density, biomass and in enhancing the weed control efficiency 40.9% and 38.0% during 2012 and 2013 at 60 DAS, respectively. The maximum rice grain, straw and biological yield was found with application of bispyribac + azimsulfuron (25 g + 35 g/ha) + 0.25% NIS as post-emergence at 15-20 DAS and was significantly superior over rest of the treatments during both the years of study.