A field experiment was conducted at KVK, South Tripura during the Kharif season of 2013 and 2014 to study the integrated weed management in direct-seeded upland rice. The predominant weed flora in the experimental field were Amaranthus viridis, Oldenlendia corymbosa, Spilanthes acmella, Ludwigia parviflora, Cleome rutidosperma, Malvestrum coromondalianeum among the broad-leaf weeds, Digitaria sanguinalis among grasses and Cyperus iria among sedges. The results revealed that though the hand weeding thrice at 15, 30 and 45 DAS recorded lowest weed dry weight and the highest grain yield, it was not economically viable. The pre-emergence application of pendimethalin at 1.0 kg/ha at 2 DAS + bispyribac-sodium at 25 g/ha at 20 DAS recorded the highest net returns and return per rupee invested and appeared to be the most promising and remunerative weed management practices for direct-seeded rice under Tripura condition followed by pendimethalin at 1.0 kg/ha at 2 DAS + one hand weeding at 30 DAS.