A field experiment was conducted for two consecutive Kharif seasons of 2014 and 2015 at research farm of AICRP-Weed Management, AAU, Anand to study the integrated weed management in cotton under irrigated condition. Pre-emergence application of pendimethalin 1000 g/ha fb hand weeding twice at 20 and 50 DAS, and pyrithiobac-sodium + quizalofop-p-ethyl (62.5 + 50 g/ha) as PoE fb directed spray of glyphosate 2000 g/ha at 60 DAS recorded significantly lower weed dry biomass as well as higher seed cotton yield and benefit cost ratio as compared to rest of the treatments. The weed control efficiency of these treatments proved to be 90 and 86% during 2014 and 2015, respectively.