Field experiment was conducted during rainy seasons of 2014 and 2015 to study the effect on weed management practices in wet direct-seeded rice (Oryza sativa L.) in Cauvery command area of Karnataka under irrigated condition with eight treatments replicated thrice. Pre-emergence application of bensulfuron-methyl + pretilachlor GR (Londax Power) at 660 g/ha fb bispyribac-sodium (Nominee Gold) at 25 g/ha at 20 days after sowing (DAS) significantly reduced weed growth and recorded the higher seed yield (4.80 t/ha), net monetary returns (` 25631/ha) and B:C ratio (1.62) and it was at par with other sequential treatments, viz. pre-emergence application of pendimethalin at 1.0 kg/ha (Stomp) fb post-emergence application of bispyribac-sodium, pre-emergence application of bensulfuron-methyl + pretilachlor, application of pendimethalin as pre-emergence fb 1 HW. Uncontrolled weed growth caused 55.2% reduction in seed yield of wet seeded rice.