A field experiment was conducted during winter season of 2005-06 and 2006-07 to evaluate the effect of nitrogen levels and weed control on weed growth, productivity and economics of wheat. The treatments comprised of 4 levels of nitrogen, viz. 0, 40, 80, and 120 kg/ha in main plots and 5 weed control methods, viz. weedy control, 2,4-D Na 0.75 kg/ha as post-emergence, isoproturon 1.0 kg/ha as post-emergence, isoproturon 1.0 kg/ha + 2,4-D Na 0.75 kg/ha as post-emergence and weeding by Dutch hoe at 15, 30 and 45 days after sowing. Maximum density and dry weight were recorded with 120 kg N/ha and minimum under N0. Increasing levels of nitrogen from 0 to 40, 40 to 80 and 80 to 120 kg/ha increased weed density by 33.7, 39.9 and 47.3% and weed dry matter by 35.2, 24.9 and 13.5%, respectively while N up take by 68.8, 56.7 and 18.7% phosphorus 13.2, 4.6 and 4.4% and potassium 16.2, 7.0 and 8.7% over preceding lower levels. 120 kg N/ha recorded significantly higher grain (2.90 t/ha) and straw (4.6 t/ha) yield, net return ( 26,616/ha) and B:C ratio (1.52).