Effect of herbicide combinations were evaluated in Raipur (Chhattisgarh) on crop growth, weed suppression and rice yield in direct-seeded rice (DSR) system during 2014 and 2015. Results revealed that combination of pyrazosulfuron + pretilachlor provided wide spectrum weed control at 15 + 600 g/ha to 30 + 1200 g/ha (61.6 - 81.5%), which was comparable to two hand weeding at 15 and 30 days after sowing. Weed control efficiency was recorded to the tune of 40.0 - 89.9%, with highest in two hand weeding (84.6 - 89.9%) and lowest in pendimethalin and lowest dose of pyrazosulfuron + pretilachlor in 2014 (40.0%) and pyrazosulfuron alone in 2015 (48.5%). The crop growth parameters (tillers, total dry matter/hill and leaf area index), yield attributes (panicle length, panicle weight, filled grains/panicle) and grain yield were recorded highest in two hand weeding (2.69 t/ha in 2014 and 5.87 t/ha in 2015) followed by pyrazosulfuron + pretilachlor at 15 + 600, 16.88 + 675 and 30 + 1200 g/ha. However, the least rice grain yield was recorded under weedy plot (1.45 t/ha in 2014 and 2.17 t/ha in 2015). The results suggested that pyrazosulfuron + pretilachlor at 15 + 600, 16.88 + 675 and 30 + 1200 g/ha were the best broad spectrum effective herbicide in order to minimize the diverse weed flora in DSR system.