Field experiments were conducted during rainy and winter seasons of 2016-17 in Kalliyoor Panchayat (8.44550 N and 76.99180 E), Nemom block, Thiruvananthapuram district, Kerala, India in order to assess the bioefficacy of flucetosulfuron in wet-seeded rice. The experiment was laid out in a randomised block design with 12 treatments and three replications. Flucetosulfuron 20, 25 and 30 g/ha applied at 2-3, 10-12 and 18-20 days after sowing (DAS) along with hand weeding at 20 and 40 DAS and weedy check comprised the treatments. Pooled analysis of the data for two seasons revealed the significance of time of application of flucetosulfuron in wet-seeded rice. Application of flucetosulfuron 25 g/ha at 10-12 DAS recorded the highest grain yield (8.33 t/ha), which was at par with flucetosulfuron 20 and 30 g/ha at 10-12 DAS and hand weeding at 20 and 40 DAS. Yield reduction due to weeds was found to be 52.33 and 55.61 per cent during rainy and winter seasons respectively. Higher yield attributes, harvest index, net income and B:C ratio were recorded for flucetosulfuron, applied at 10-12 and 18-20 DAS, irrespective of their dosage. The lower weed dry weight and weed index of these treatments substantiate the result. Henceforth, flucetosulfuron 20, 25 and 30 g/ha with a wide application window of 10-20 DAS can be endorsed for better weed management and higher yield in wet seeded rice.