A field experiment was conducted during the winter season of 2012-13 and 2013-14 at ICAR-DWR, Jabalpur, Madhya Pradesh, to study the effect of crop establishment and weed management practices on growth and yield of wheat. Maximum reduction in density and biomass of Phalaris minor and Avena ludoviciana was recorded under zero-tillage with residue while in Medicago denticulata under conventional tillage practices. Zero tillage with residue retention recorded higher grain and straw yield as well as net return and B:C ratio. Among the different herbicides ready mix application of sulfosulfuron + metsulfuron (32 g/ha) significantly reduced weed density and dry biomass accumulation, and which was followed by application of mesosulfuron +iodosulfuron and mertibuzin  over weedy check due to enhanced of growth, yield and benefit cost ratio of wheat. As compared to weedy, the higher yield attribute character and yield of wheat was produced with the herbicidal treatments. The maximum yield, net return and B:C was achieved with the post-emergence application of sulfosulfuron + metsulfuron.