Sensitivity of sulfosulfuron, ethoxysulfuron, mesosulfuron + iodosulfuron (RM), glyphosate, metribuzin and imazethapyr against Himsona and Rocky hybrids of tomato and their residues in fruits and soil were evaluated in a field and screen house study during Kharif 2015 and 2016, respectively. Herbicides applied at different stages and doses caused injury to tomato seedlings in both hybrids up to 30 days after treatment (DAT). Phyto-toxicity was more prominent in case of mesosulfuron + iodosulfuron (RM) followed by ethoxysulfuron and glyphosate. Among both hybrids, herbicide toxicity was more in Rocky as compared to Himsona irrespective of dose and time of application. But crop recovered fully within 30 days in plots treated with sulfosulfuron at 25 g/ha either used as pre-plant incorporation (PPI) or pre-emergence (PE) and post emergence (PoE) applications of 25 g/ha twice on 15 and 45 DAT, respectively resulting in more number of fruits per plant and was on par with untreated check. For herbicides residues estimation, recovery experiments were performed by validation of analytical method at two fortification levels of 0.01 and 0.05 μg/g which gave average recoveries of different herbicides from 80.4 to 91.3%. The limit of detection (LOD) and limit of quantification (LOQ) of various herbicides were ranged from 0.003 to 0.01 μg/g. In tomato fruits, residues of these herbicides were below maximum residues limit (MRL) of 0.05 μg/g. Residues in soil ranged from 0.023 to 0.186 μg/g in various herbicide treatments. Sulfosulfuron application at 25 g/ha was found safe for Orobanche management in tomato.