A field experiment was conducted during Kharif seasons of 2014, 2015 and 2016 with an objective to assess the feasibility of weed and nutrient management in direct-seeded rice. The experiment was laid out in a factorial RBD with eighteen treatment combinations including six weed management treatments, viz. pretilachlor, pendimethalin, pretilachlor followed by (fb) bispyribac-sodium, pendimethalin fb bispyribac-sodium, weed free and weedy check and three nitrogen (N) levels, viz. 80, 100 and 120 kg N/ha with three replications. Significantly lower weed biomass was recorded with weed free which [2 hand weedings (HW) at 20 and 40 days after seeding (DAS)] was at par with pendimethalin 1.0 kg/ha pre-emergence treatment (PE) fb bispyribac-sodium 0.04 kg/ha, post-emergence treatment (PoE). Similarly, the highest weed control efficiency (WCE, 73.0%) and the lowest weed index (WI) were also recorded with weed free treatment, followed by pendimethalin 1.0 kg/ha fb bispyribac sodium 0.04 kg/ha (WCE, 71.2%).  Rice growth and yield attributes, viz. plant height, effective tillers, panicles length, grains/panicle were improved significantly under combine application of  PE  and  PoE herbicides either pendimethalin 1.0 kg/ha or pretilachlor  0.75 kg/ha (PE) fb  bispyribac 0.04 kg/ha (PoE) and weed free [2 HW at 20 and 40 DAS]. Further, weed free treatment as well as pendimethalin 1.0 kg/ha fb bispyribac 0.04 kg/ha were found equally effective and recorded significantly higher rice grain and straw yield and nutrient use efficiency (NUE) with higher net returns compared to rest of treatments. Application of 120 kg N/ha significantly increased the plant height, effective tillers/plant, panicle length, grain/panicle, grain and straw yield, N content and NUE % over rest of the treatments in all aspects of yield and yield attributes. It was concluded that 2 HW at 20 and 40 DAS or application of pendimethalin 1.0 kg/ha fb bispyribac-Na 0.04 kg/ha for weed control appeared to be a viable strategy along with 120 kg N/ha for achieving higher and profitable yield of direct-seeded rice.