An experiment was conducted at Agricultural Research Station, Dhadesugur, UAS, Raichur, Karnataka during 2015-16 and 2016-17 to study the effect of weed control practices on growth and yield of sugarcane and its associated weeds. Dominant weeds were Echinochloa spp. (E. crus-galli and E. colona), Dactyloctenium aegyptium, Eleusine indica, Brachiaria spp. (B. mutica and B. ramosa) and Digitaria sanguinalis among grasses, Eclipta alba, Chenopodium album, Physalis minima, Ageratum conyzoides, Parthenium hysterophorus and Portulaca oleracea as broad-leaf weeds and Cyperus spp. (C. rotundus and C. iria) as sedges. Among the herbicidal treatments, pyrazosulfuron-ethy + metribuzin + 2,4-D sodium salt WDG (3000 g/ha) recorded significantly higher millable cane yield (119.5 t/ha) as compared to other treatments due to lower weed biomass (42.7 and 47.0 g/m2 at 45 and 75 DAP, respectively) and higher weed control efficiency at 45 and 75 DAP (86.4 and 85.5% at 45 and 75 DAP, respectively) during 2015-16. Similar trend was observed in 2016-17.