Cyperus rotundus is one of the most invasive perennial sedge weed considered as the world’s worst weed. The tubers of the weed remain viable for more than three years and pass over the harsh weather period by preventing the germination of buds present in the tubers. Due to dormancy, the tubers may sustain in the soil for longer and interfere with the crops raised in the following season. Phenols are considered as the major factor of dormancy in Cyperus rotundus tubers. Among different phenolic acids, vanillic acid is dominated, found under long and continuous stress. Nanoparticles are capable to degrade the phenols. In order to confirm whether the nanoparticles have effect on degradation of phenol present in Cyperus rotundus, the dominant phenol present in the tuber i.e., vanillic acid was chosen. Experiment was conducted at the department of Nano Science and Technology, Tamil Nadu Agricultural University, Coimbatore to find the effect of different nanoparticles such as iron oxide, silver, titanium dioxide and zinc oxide on commercially available vanillic acid degradation during 2013-15. The maximum degradation of vanillic acid was observed with iron oxide nanoparticles at 25 mg i.e., 60.6% degradation compared to control. Titanium dioxide, zinc oxide and silver nanoparticles at 25 mg recorded the 54.5, 49.3 and 24.8% degradation, respectively.