A field experiment was conducted during rainy (Kharif) season of 2014 and 2015 at Zonal Agricultural Research Station, V. C. Farm, Mandya, Karnataka to study the efficacy of sequential application of herbicides on weed density, weed dry weight, yield and economics of dry direct-seeded rice. The results revealed that pre-emergence application of bensulfuron-methyl 0.6% + pretilachlor 6% GR at 10 kg/ha fb post-emergence application of bispyribac-sodium at 25 g/ha at 20 days after sowing (DAS) recorded significantly lower total weed population (39.4 and 43.1/m2) and weed dry weight (8.2 and 9.0 g/m2) with weed control efficiency of 77.8 and 77.2% during 2014 and 2015, respectively. As a consequence of effective weed control the same treatment recorded significantly higher grain yield (4.60 and 4.42 t/ha), net monetary returns (` 39,340 and 36,710/ha) and B: C ratio (2.32 and 2.23) during 2014 and 2015, respectively. This treatment was statistically comparable to hand weeding thrice at 20, 40 and 60 DAS. Uncontrolled weed growth caused 56% reduction in grain yield of dry direct-seeded rice.