Evolution of multiple herbicide resistance in Phalaris minor in wheat has resulted from the repeated use of herbicides with a similar mode of action which could threaten the sustainability of the rice-wheat cropping system in North-West India. In this context, field studies were conducted at Research Farm, Department of Agronomy, Punjab Agricultural University, Ludhiana during 2011-12, 2012-13 and 2013-14 in randomized block design replicated four times and at farmer’s field during 2016-17 and 2017-18 with the objective to evaluate the efficacy of herbicide with alternative mechanism of action for the control of resistant P. minor in wheat. The treatments included pyroxasulfone 85, 102, 127.5 g/ha, pendimethalin 750 g/ha as pre-emergence (PE), sulfosulfuron 25 g/ha, clodinafop 60 g/ha as post-emergence (PoE) and unsprayed control. However, the treatments during 2013-14 included pyroxasulfone 85, 102, 127.5 g/ha, pendimethalin 750 g/ha and unsprayed control with pendimethalin 1125 g/ha as PE at farmers’ field instead of pendimethalin 750 g/ha. The results indicated that pyroxasulfone at 127.5 g/ha recorded effective control of P. minor and its biomass and gave the highest wheat grain yield (4.87, 4.80 and 5.43 t/ha) during 2011-12, 2012-13 and 2013-14, respectively. At farmer’s field, pyroxasulfone 127.5 g/ha has been found effective against the resistant populations of Phalaris with 5.37 and 5.42 t/ha grain yield. The current study demonstrated that PE application of pyroxasulfone at 127.5 g/ha would be a suitable option for the control of resistant populations of Phalaris in wheat in Punjab.