A field experiment was conducted at Research Farm of College of Agriculture, Tikamgarh, Madhya Pradesh during Kharif, 2016 to find out the suitable herbicides for weed control in sesame. The experiment was laid out in a randomized block design with twelve treatments, viz. pre-emergence application of pendimethalin at 750 g/ha, post-emergence herbicides; quizalofop-ethyl at 40 and 50 g/ha, fenoxaprop-ethyl at 75 and 100 g/ha, pendimethalin at 750 g/ha fb quizalofop at 40 and 50 g/ha, pendimethalin at 750 g/ha fb fenoxaprop at 75 and 100 g/ha, pendimethalin fb one hand weeding at 20 DAS, two hand weeding at 15 and 30 DAS and weedy check. Hand weeding twice at 15 and 30 DAS recorded the lowest intensity and dry weight of total weeds (2.74 g/m2) followed by pendimethalin fb one hand weeding (3.35 g/m2) and these treatments significantly reduced the intensity and dry weight of total weeds over rest of the herbicidal treatments and weedy check. Pre-emergence application of pendimethalin fb post-emergence, quizalofop and fenoxaprop significantly reduced the weed dry weight over alone application of pendimethalin. The net profit was the highest under two hand weeding (` 35,099/ha) followed by pendimethalin 750 g/ha fb one hand weeding (` 30,365/ha) and pendimethalin fb fenoxaprop-ethyl at 100 g/ha (` 27,811/ha), whereas the B:C ratio was higher under the application of pendimethalin 750 g/ha fb fenoxaprop-ethyl 100 g/ha (2.72).