Direct-seeded rice (DSR) helps in saving water and is beneficial for soil physical health along with environmental benefits, but weeds poses a serious threat to efficient crop production. In the absence of ponded water, weeds emerge in several flushes making it difficult to manage them with a single pre- or post-emergence herbicide application.  Studies were carried out under the screen house conditions at CCS Haryana Agricultural University, Hisar, where the response of four dominant grass weeds of direct-seeded rice, viz. Echinochloa glabrescens, Leptochloa  chinensis, Eragrostis japonica and  Dactyloctenium  aegyptium was evaluated against pendimethalin and cyhalofop-butyl + penoxsulam mixture. The four grassy weed species were planted in pots replicated four time with 20 seed per plot. Pendimethalin was applied as pre-emergence at 0.25, 0.5, 1.0 and 2.0 kg/ha and cyhalofop-butyl + penoxsulam mixture was sprayed as post-emergence (PoE) (at 25 days after sowing) at 32.5, 65, 135 and 270 g/ha with the help of knapsack sprayer and control pots were maintained for each species and herbicides. Periodical observations on visual mortality (0-100 scale, where 0 = no effect and 100=complete mortality) and dry weight per pot was observed at harvest. Application of pendimethalin at 1.0 kg/ha resulted in excellent control of L. chinensis and D. aegyptium, whereas at 2.0 kg/ha application rate killed all the weeds. Cyhalofop-butyl + penoxsulam applied at 270 g/ha showed 100% mortality of E. glabrescens and L. chinensis.  However, the highest rate (270 g/ha) of this mixture had no effect on E. japonica, and provided only 20% control of D. aegyptium. Results of this study suggest that pendimethalin can be used for managing E. glabrescens, L. chinensis, E. japonica and D. aegyptium. However, cyhalofop-butyl + penoxsulam can be used as PoE in fields dominated by E. glabrescens and L. chinensis.