During 2014-17, an on-farm research trial was conducted at five farmer fields in Katni district of Madhya Pradesh to validate, refine and popularize the technology for managing Commelina benghalensis L. The study aimed to find out the efficacy of bispyribac-sodium 20 g/ha, pyrazosulfuron 20 g/ha and pendimethalin 1.5 kg/ha over farmers practice (hand weeding twice at 30 and 60 DAT) and unweeded control on the management of weeds and profitability of rice (Oryza sativa) sown in transplanted condition. Bispyribac-sodium 20 g/ha at 20-21 DAT reduced the density of C. benghalensis upto 9.8 no./m2 and dry weight upto 6.9 g/m2 and also reduced the infestation of other weeds to a significant extent. Higher values of yield attributes such as number of panicles (229/m2), grain yield (3.46 t/ha) and net returns (` 31820/ha), as well as less values of nutrient uptake by weeds (5.8 kg N, 1.1 kg P and 6.9 kg K/ha) were recorded with this herbicide compared to farmers practice.