An experiment was conducted under All India Network Research Project on Onion and Garlic, operating at the College of Horticulture, Orissa University of Agriculture and Technology, Sambalpur, Odisha during Rabi, 2010-11 to compare the efficacy of different weed control methods in onion. The experiment was laid out in a randomized block design with eight combinations of weed management practices and replicated thrice. Results revealed that significantly highest marketable bulb yield (19.19 t/ha) and total bulb yield (22.80 t/ha) was obtained with a higher percentage ‘A’ grade bulb (34.04 %) and an average bulb weight (69.83 g) by the application of oxyfluorfen before planting + one hand weeding at 45 days after transplanting. The identical weed management practice recorded highest 66.09% of weed control efficiency along with the lowest number of monocot weeds (26.33/ m2), minimum fresh weight of weeds (40.08 g/m2) and minimum dry weight of weeds (14 g/m2). Imposition of manual hand weeding at 45 DAT facilitates a weed-free situation to the crop. Hence, it was concluded that maximum bulb yield can be obtained with the application of oxyfluorfen before planting + one hand weeding at 45 DAT due to the influence of oxyfluorfen and one manual hand weeding on monocot weeds during the crop growth period.