Direct-seeded rice (DSR) is significant in modern day agriculture because it requires less water input (20%) and labour (65-80 person-days/ha). Moreover, it enables farmers to establish rice early, which allows the crop stand more power to resist flush flood happening more frequently in the beginning of the monsoon. Direct-seeded rice produces at par or higher yield compared to manual transplanted rice but significantly higher yield (1.07 t/ha) compared to traditional manual broadcasted rice followed by beushening practice. It helps to increase system productivity by 0.25 t/ha, increase income by US$ 150/ha, reduce greenhouse gas emission (20% GWP) besides instrumental in reducing straw burning and environmental footprints. Despite all these advantages, the DSR has not been adopted at large scale at farmers’ field in eastern India particularly in Bihar, Odisha and Uttar Pradesh. One of the most important reasons for this is heavy and diversified weed infestation in DSR which consequently reduces rice yields significantly. In the present review article, the authors have tried to compile relevant information on the weed management approaches in DSR with special reference to eastern Indian states. Detailed discussions on weed species based on their occurrence and infestation, critical period of weed competition and different methods of weed management in DSR in eastern Indian ecologies have been enlightened in this paper. It also includes that weed management options in DSR depend on many factors like land situation, soil condition, water status, planting geometry and resources availability; and therefore, one single method of weed management practices may not be sufficient to control all the flushes of diversified weeds. Integrated approach combining cultural, physical and chemical methods can provide a more robust control of weeds in DSR. Relevant data generated in Odisha representing eastern Indian ecologies have also been included herein to further enrich knowledge and skills regarding DSR productivity, in general and possible weed management options, in particular.