An experiment was conducted to find out the most effective method of weed management in elephant foot yam. The experiment was conducted under 10 different agro-climatic conditions of India including plains, hills and islands, etc. using RBD with 8 treatments and 3 replications, during 2017 and 2018. Cyperus rotundus, Cynodon dactylon and Commelina benghalensis were the predominant weeds at most of the locations. Among different treatments, hand weeding thrice at 30, 60, 90 days after planting (DAP) recorded taller plants (80.85 cm) with more pseudo stem girth, canopy spread (97.07 cm), leaf area (5435.37 cm2), corm yield (38.0 t/ha), and net returns ( 387253), which was at par with weed control ground cover mat mulching and application of glyphosate thrice at 30, 60 and 90 DAP. Lower weed density and biomass were recorded in treatment with weed control ground cover mat mulching, which was at par with glyphosate applied at 30, 60 and 90 DAP.