A field experiment was conducted at District Seed Farm (AB Block), Kalyani under Bidhan Chandra Krishi Vishwavidyalaya during winter season of 2016-17 and 2017-18 in upland situation to evaluate the effect of various herbicides and it’s combinations against different weed species and yield of wheat under new alluvial zone. The experiment was carried out in a randomized block design with eleven treatments in three replications. Total weed density at 30 days after spray, was recorded minimum with halauxifen-methyl-ester + florasulam + carfentrazone 10.21 + 20 g/ha and it was at par with the metsulfuron + carfentrazone 4 + 20 g/ha and considerably better than all other control measures except weed free situation. At 30 days after spray, least total weed biomass was observed with the 2,4-D E + carfentrazone 400 + 20 g/ha and showed parity with the halauxifen + florasulam + carfentrazone 10.21 + 20 g/ha, metsulfuron + carfentrazone 4 + 20        g/ha and halauxifen-methyl ester + florasulam 12.76 g/ha and statistically better than all other treatments except weed free situation. Amongst various herbicidal treatments, total weed density at 60 days after spray, lowest with halauxifen-methyl-ester + florasulam 12.76 g/ha and was at par with most of the treatments except 2,4-D Na 500 g/ha, 2,4-D Na + carfentrazone 400 + 20 g/ha and weedy check. This treatment also registered low weed biomass. The soil microbial population was significantly affected by weed control measures at 60 days after sowing.Higher grain yield of wheat was observed in weed free (4.80 t/ha) and was at par with metsulfuron + carfentrazone 4 + 20 g/ha (4.56 t/ha), halauxifen-methyl ester + florasulam + carfentrazone 10.21 + 20 g/ha (4.44 t/ha) and 2,4-D E + carfentrazone 400 + 20 g/ha (4.40 t/ha) and significantly better than other treatments. Total nutrient uptake by crop was highest in weed free and was at par with metsulfuron + carfentrazone 4 + 20 g/ha and significantly better to other treatments. From the study. It was concluded that use of metsulfuron + carfentrazone 4 + 20 g/ha resulted in maximum wheat yield followed by halauxifen-methyl ester + florasulam + carfentrazone 10.21 + 20 g/ha.