A field experiment was carried out at SKRAU, Bikaner, Rajasthan, during Rabi seasons of 2016-17 and 2017-18 to investigate the effect of tillage and weed management practices on productivity of wheat (Triticum aestivum) in North- West Rajasthan. Amongst the tillage treatments, adoption of stale seedbed (SSB) using glyphosate at 2.0 kg/ha resulted in higher dry matter at harvest, effective tillers (101.77 per m.r.l.) and grain yield (4.06 t/ha), and significantly lowered the density and dry matter of weeds. Among various weed management treatments, metsulfuron 4.0 g/ha + one hand weeding (HW) at 45 DAS significantly lowered the density and dry matter of all the broad-leaf weeds, but not effective against Cyperus rotundus and Cynodon dactylon. Being at par with weed free check and also 2,4-D E + one HW, it was significantly superior to all other treatments and resulted 4.40 t/ha grain yield of wheat.