A field experiment was conducted at Agronomic Research Station of Doon (P.G) College of Agriculture Science and Technology, Rampur (Selaqui) Dehradun, Uttarakhand during 2018-19 to study the effect of different herbicides in wheat. The experimental soil was sandy loam in texture, slightly acidic in nature with low in N, high in available P and medium in K. The results revealed that post-emergence application of sulfosulfuron 25 g/ha, followed by metsulfuron-methyl 4.0 g/ha gave the highest yield of wheat which was at par with manual weeding at 30, 60 and 90 DAS. Based on the results, hand weeding at 30, 60 and 90 days after sowing in wheat recorded the lowest values of weed count and biomass with the highest weed control efficiency, and also showed superiority over rest of the treatments. Among the herbicides, sulfosulfuron at 25 g/ha applied as post-emergence produced grain yield of wheat 3.49 t/ha, which increased the grain yield of wheat to the tune of 24.2, 35.8, 46.0, 49.8 and 103% over carfentrazone, clodinafop propargyl, pendimethalin, pinoxaden and weedy check, respectively.