A study was conducted at Jawaharlal Nehru Krishi Vishwa Vidyalaya, Jabalpur, Madhya Pradesh during Kharif 2017 and 2018 to evaluate the efficacy of pyribenzoxim herbicide in dry direct-seeded rice. Among the herbicidal treatments, pyribenzoxim 5% EC 60 g/ha was the most suitable for controlling weeds, followed by oxadiargyl 80% WP 100 g/ha, though hand weeding treatment showed lowest weed infestation and maximum grain yield (4.55 t/ha). Weed density and weed dry weight had strong negative correlation with grain yield (r = -0.982** and -0.983**, respectively). Total weed population and biomass was the lowest in manually weeded plots followed by pyribenzoxim 5% EC 60     g/ha. The highest weed control efficiency (70.0, 86.7 and 88.3% at 30, 45 and 60 DAS, respectively), weed control index (82.9, 85.5 and 86.4% at 30, 45 and 60 DAS, respectively) and herbicide efficiency index (43.4%) were found with pyribenzoxim 5% EC 60 g/ha. The pyribenzoxim 5% EC 60 g/ha at 15 DAS was found the most remunerative with benefit-cost ratio of 2.42.