Field experiment was conducted at CCS Haryana Agricultural University during Rabi 206-17 and 2017-18 to evaluate bio-efficacy of different herbicides and their combination against cross resistant P. minor in wheat, and to study the phytotoxic effects on the crop, if any. The treatments included application pre-emergence herbicides pendimethalin 1500 g/ha and its mixture with metribuzin 175 g/ha alone, pendimethalin + pyroxasulfone  Tank mix (TM) at 1500 + 102 g/ha alone and their sequential application with post-emergence herbicides application (PoE) of mesosulfuron + iodosulfuron ready mix (RM) 14.4 g/ha and pinoxaden 60 g/ha along with weedy check treatment. The minimum density of P. minor, weed biomass and the highest wheat grain yield was observed with pendimethalin + pyroxasulfone TM fb mesosulfuron+ iodosulfuron RM (1500 + 102 fb 14.4 g/ha). All the herbicides significantly reduced the weed biomass as compared with the control but maximum reduction in the weed biomass was achieved with pendimethalin + pyroxasulfone TM fb mesosulfuron+ iodosulfuron RM. Pinoxaden at 60 g/ha did not control Rumex dentatus and Chenopodium album. Only pre-emergence application of metribuzin, pendimethalin + metribuzin (before sowing), pinoxaden + metribuzin TM caused toxicity of up to 5% at 10 days after treatment (DAT). The wheat recovered from toxicity by 20 DAT without any yield penalty. On-farm demonstrations of pyroxasulfone at 127.5 g/ha PE in Haryana revealed 88.3 % control of multiple herbicide resistant P. minor. Its integration with pendimethalin at 1.5 kg/ha (PE) and post-emergence herbicides at 35 DAS has improved control of P. minor to 92.1%.