A field experiment was conducted during Rabi seasons of 2015-16 and 2016-17 to study the effect of nitrogen and weed control on wheat yield, nitrogen uptake and economics of wheat. The treatments comprised of 4 levels of nitrogen, viz. 90, 120, 150 and 180 kg/ha, and 5 weed control methods, viz. weedy check, hand weedings at 30 and 60 days after seeding (DAS), clodinafop + metsulfuron (60 + 4 g/ha), fenoxaprop + metsulfuron (120 + 4 g/ha) and sulfosulfuron + metsulfuron (25 + 4 g/ha). Weed density was reduced with increased rate of nitrogen from 90 to 180 kg/ha. Crop fertilized with180 kg N/ha was at par with 150 kg N/ha but produced significantly higher weeds biomass than the rest of the nitrogen levels. The uptake of nitrogen by weeds was significantly higher with 180 kg/ha than the other N-levels. Post-emergence spray of clodinafop + metsulfuron (60 + 4 g/ha) recorded significantly the lowest weed population followed by sulfosulfuron + metsulfuron (25 + 4 g/ha) and fenoxaprop + metsulfuron (120 + 4 g/ha). Hand weeding twice (30 and 60 DAS) recorded the significantly lowest weeds biomass, followed by clodinafop + metsulfuron (60 + 4 g/ha). Weedy check recorded significantly maximum amount of nitrogen uptake by weeds. Nitrogen applied at 180 kg/ha recorded the highest wheat grain yield (3.82 and 3.98 t/ha), crop nitrogen uptake (96.81 and 99.69 kg/ha), gross returns ( 73700/ha), net returns ( 49600/ha) and B:C ratio (2.06).