Phalaris minor is seriously affecting wheat productivity and profitability in Haryana. The menace of P. minor has worsened after it evolved resistance to herbicides. For rational recommendation and implementation of management strategies, it is imperative to assess and quantify the level of resistance in P. minor populations. In dose-response assay, it was found that P. minor populations ‘Naggal’ and ‘Kalvehri’ exhibited multiple resistance to herbicides from different chemical families. ‘Naggal’ was 13-, 18-, 26- and 22-fold resistant to clodinafop, pinoxaden, sulfosulfuron and mesosulfuron + iodosulfuron, respectively and ‘Kalvehri’ was 15-, 29- and 16-fold resistant to pinoxaden, sulfosulfuron and mesosulfuron + iodosulfuron, respectively. All tested populations were resistant to ACCase inhibitors with more number of populations being highly resistant to clodinafop than pinoxaden. However, majority of the populations were susceptible to ALS inhibitors particularly mesosulfuron + iodosulfuron. The evolution of multiple herbicide resistance in P. minor is a big challenge for scientists and farmers alike.