Impact of integrated weed management practices involving stale seedbed, mulching with dried banana leaves, herbicides, viz. pre-emergence (PE) diclosulam, post-emergence (PoE) quizalofop-p-ethyl and imazethapyr and manual weeding on nodulation in bush cowpea and enzyme activity in soil was studied. Stale seedbed recorded significantly higher number of total nodules per plant. Dehydrogenase enzyme activity was also higher in stale seedbed however, urease enzyme activity did not have any significant effect at 15 and 30 DAS. Treatments with imazethapyr recorded lesser number of total nodules than treatments with diclosulam and quizalofop-p-ethyl. Among the herbicide treatments at 15 DAS, PE diclosulam registered significantly higher urease and dehydrogenase enzyme activity than weedy check and comparable activity with hand weeding treatment. Post-emergence imazethapyr showed a reduction in dehydrogenase and urease enzyme activity at 30 DAS compared to 15 DAS. However, PoE quizalofop-p-ethyl registered higher dehydrogenase and urease enzyme activity at 30 DAS compared to 15 DAS and values were comparable or higher than that of hand weeding treatment.