Field experiments were conducted to study the chemical and non-chemical weed management on weed spectrum, yield and economics of direct-seeded rice (DSR) under lowland irrigated condition at Regional Research Station, Tamil Nadu Agricultural University, Paiyur, Tamil Nadu, India in wet and dry seasons of 2013-14 and 2014-15. The results revealed that application of pyrazosulfuron-ethyl 10% WP at 20 g/ha at 3 DAS fb mechanical weeding with cono-weeder at 25 DAS recorded higher weed control efficiency (WCE) of 94% and higher grain yield of 6.45 t/ha, gross income of  82669/-, net income of  48767/- with the benefit : cost ratio of 2.45. It recorded 56% higher grain yield over weedy check and 14% higher yield over pyrazosulfuron-ethyl. Hence, pre-emergence application (3 DAS) of pyrazosulfuron-ethyl 10% WP at 20 g/ha followed by mechanical (cono-weeder) at 25 DAS was effective for weed management in DSR.