A field experiment was conducted during Kharif (rainy season) 2016 and 2017 in sandy clay loam soils of experimental field at Banaras Hindu University, Varanasi, Uttar Pradesh India to find out the effect of leaf colour chart-based nitrogen and weed management practices on nutrient uptake and yield of direct-seeded rice. Minimum weed index, nutrient content and uptake by weeds and maximum weed control efficiency, yield and nutrient content and uptake by grain and straw were observed with application of nitrogen leaf colour chart LCC < 5. Application of pyrazosulfuron 20 g/ha (PE) fb bispyribac 25 g/ha at 15-20 DAS recorded minimum weed index, nutrient content and uptake by weeds and maximum weed control efficiency, rice yield and nutrient content and uptake by rice grain and straw, which was comparable with two hand weedings at 20 and 40 DAS.