A field study was conducted during 2016-17and 2017-18 to evaluate the impact of four tillage systems, viz. zero tillage (ZT) both in rice and wheat, conventional tillage (CT) both in rice and wheat, ZT in rice – CT in wheat and CT in rice –ZT in wheat with four weed management practices (recommended herbicide, recommended herbicide + one hand weeding, weed free and weedy check) in dry seeded rice–wheat cropping system on a lateritic soil of West Bengal. Among weed management practices, application of sulfosulfuron + metsulfuron at 0.032 kg/ha at 20 DAS followed by one hand weeding at 40 DAS in wheat was found to be the most effective. The yield of wheat under ZT-ZT was found to be the highest (3.78 t/ha), which was at par with CT-ZT. Advantages in ZT-ZT were to the extent of 23.6 and 21.8% over CT-CT in first and second year, respectively. Among weed management practices, recommended herbicide followed by one hand weeding registered higher yield (3.78 t/ha) and was comparable with the weed free treatment. The highest B:C ratio was recorded in zero tillage in wheat (ZT-ZT and CT-ZT) in combination with the sole application of recommended herbicide. The continuous ZT, especially in wheat with recommended herbicide alone was promising for higher productivity and profitability under dry-seeded rice–wheat system on lateritic soils of Eastern India.