A field experiment was conducted to assess the effect of tillage, seed rate and nitrogen levels on weed and yield of wheat at College of Agriculture, S.K. Rajasthan Agricultural University, Bikaner during Rabi (winter) seasons of 2015-16 and 2016-17. It was laid out in a split plot design with three replications with six main plots comprising three levels of tillage (conventional, minimum and zero tillage) and two levels of seed rate (100 and 125 kg/ha) and four levels of nitrogen (80, 100, 120 and 140 kg N/ha) as sub-plots and comprising a total of 24 treatment combinations.  The conventional tillage significantly increased the grain, straw and biological yields of wheat over zero and minimum tillage. Conventional tillage lowered the weed density and weed biomass as compared to zero and minimum tillage systems. Seed rate of 125 kg/ha and application of 120 kg N/ha significantly increased the grain, straw and biological yields over 100 kg/ha seed rate and 80 and 100 kg N.