A field experiment was conducted at Pandit Jawaharlal Nehru College of Agriculture and Research Institute (PAJANCOA&RI), Karaikal during September 2013 - January 2014 with ten treatments replicated thrice in a randomized block design to evaluate the weed management efficacy of sequential application of pendimethalin and bispyribac-sodium in aerobic rice. Echinochloa colona (28.1%), Ludwigia abyssinica (28%) and Cyperus difformis (19.8%) among grasses, broad-leaved weeds and sedges, respectively were the predominant in the experimental field. Among the weed control treatments, pendimethalin 1.0 kg/ha at 3 days after seeding (DAS) fb bispyribac-sodium 30 g/ha at 30 DAS was found to be effective recording lowest weed density and biomass and superior growth attributes, yield attributes and yield of rice (4.86 t/ha).