Field experiments were conducted during Rabi (winter season) 2018-19 and 2019-20 to study the effect of sequential application of herbicides on productivity and profitability of transplanted rice. Pre-emergence (PE) application of pretilachlor 750 g/ha fb ready-mix post-emergence (PoE) application of triafamone + ethoxysulfuron 60 g/ha recorded significantly higher grain yield which was found to be at par with two hand weedings. Sequential application of pretilachlor 750 g/ha fb triafamone + ethoxysulfuron 60 g/ha proved to be more effective in minimising total weed biomass (5 g/m2), weed index (4%) and enhancing weed control efficiency (96%), grain yield (5.4 t/ha), net returns (47.0 x103 /ha) and benefit cost ratio (1.9) than weedy check. Tank-mix application of fenoxaprop-p-ethyl 60 g/ha with ethoxysulfuron 18.75 g/ha or chlorimuron + metsulfuron 4 g/ha after pretilachlor 750 g/ha showed phytotoxicity at 5 days after application (DAA) of herbicide, which got recovered at 30 DAA.