Field experiments were conducted to evaluate the bio-efficacy and phyto-toxicity of sodium acifluorfen 16.5% + clodinafop-propargyl 8% EC as post-emergence against weed flora in groundnut during Kharif (rainy season) 2015 and summer 2016 at UAS, GKVK, Bengaluru, Karnataka. Different post-emergence herbicides were applied at 22 days after sowing (DAS) and compared with two rounds of hand weeding at 20 and 45 DAS. The results revealed that sodium acifluorfen 16.5% + clodinafop-propargyl 8% EC (206.25 + 80 g/ha) recorded higher pod (1.44 and 1.65 t/ha) and haulm yield (1.59 and 1.89 t/ha) in 2015 and 2016. Higher economic yield under this treatment was attributed to the reduced weed density, weed dry weight, weed index and higher weed control efficiency and higher herbicide efficiency index. Post-emergence application of sodium acifluorfen 16.5% + clodinafop-propargyl 8% EC was found non-phytotoxic to groundnut as well as succeeding crop (finger millet).